GPATCH3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPATCH3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPATCH3 at tissue level.

III. Associated gene sets

GO_0032480Biological processnegative regulation of type I interferon production
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0039536Biological processnegative regulation of RIG-I signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameGPATCH3
Protein nameG-patch domain containing 3
G patch domain-containing protein 3
SynonymsGPATC3
DescriptionFUNCTION: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development . Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 . .

AccessionsENST00000450844.1
ENST00000361720.10
ENST00000445019.5
H0Y5H5
Q5JYG5
Q96I76