GNL3L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0033234Biological processnegative regulation of protein sumoylation
GO_0032091Biological processnegative regulation of protein binding
GO_1904816Biological processpositive regulation of protein localization to chromosome, telomeric region
GO_0042254Biological processribosome biogenesis
GO_0031647Biological processregulation of protein stability
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0016020Cellular componentmembrane
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameGNL3L
Protein nameG protein nucleolar 3 like
G protein nucleolar 3 like (Guanine nucleotide binding protein-like 3 (Nucleolar)-like, isoform CRA_b)
GNL3L protein
Guanine nucleotide-binding protein-like 3-like protein
SynonymshCG_1810878
DescriptionFUNCTION: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. .

AccessionsENST00000674238.1
Q05DU1
Q9NVN8
ENST00000674311.1
ENST00000336470.8
ENST00000674178.1
A0A6I8PS19
ENST00000674229.1
A0A6I8PL80
ENST00000360845.3
A0A6I8PL58
ENST00000674420.1
A0A6I8PL53
ENST00000674498.1
ENST00000674225.1