GM2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007611Biological processlearning or memory
GO_0050885Biological processneuromuscular process controlling balance
GO_0051651Biological processmaintenance of location in cell
GO_0046479Biological processglycosphingolipid catabolic process
GO_0019915Biological processlipid storage
GO_0009313Biological processoligosaccharide catabolic process
GO_0006869Biological processlipid transport
GO_0006689Biological processganglioside catabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_0016324Cellular componentapical plasma membrane
GO_0005576Cellular componentextracellular region
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043202Cellular componentlysosomal lumen
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016004Molecular functionphospholipase activator activity
GO_0030290Molecular functionsphingolipid activator protein activity
GO_0005319Molecular functionlipid transporter activity
GO_0032428Molecular functionbeta-N-acetylgalactosaminidase activity

IV. Literature review

[source]
Gene nameGM2A
Protein nameAlternative protein GM2A
Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short]
Ganglioside GM2 activator
Synonyms
DescriptionFUNCTION: The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity). Has cholesterol transfer activity . .

AccessionsENST00000357164.4
H0YBY3
E5RJD0
L0R4Y4
ENST00000523466.5
ENST00000523004.1
P17900