GEMIN2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GEMIN2 at tissue level.

III. Associated gene sets

GO_1905215Biological processnegative regulation of RNA binding
GO_0000245Biological processspliceosomal complex assembly
GO_0008380Biological processRNA splicing
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0006397Biological processmRNA processing
GO_0000387Biological processspliceosomal snRNP assembly
GO_0005730Cellular componentnucleolus
GO_0097504Cellular componentGemini of coiled bodies
GO_0034719Cellular componentSMN-Sm protein complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016604Cellular componentnuclear body
GO_0005681Cellular componentspliceosomal complex
GO_0032797Cellular componentSMN complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGEMIN2
Protein nameGem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1)
Gem-associated protein 2
Gem nuclear organelle associated protein 2
SynonymsSIP1
DescriptionFUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs . Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) . In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP . To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A . Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP . Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound . .

FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. .

FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. .

FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. .

AccessionsENST00000531684.6
A0A8J9FN78
H0YCF4
H0YDP6
A0A8J9FTZ9
ENST00000250379.13
ENST00000308317.12 [O14893-5]
ENST00000412033.7
O14893
ENST00000527381.2
A0A3B3IU42
S4R421
ENST00000650481.1
H0YEL0
ENST00000396249.7
ENST00000524781.1
A0A8J9FJK1
G5EA29
ENST00000534684.7
ENST00000525153.6