GDF11 | OmnibusX

Name	Number of supported studies	Average coverage
retinal bipolar neuron	3 studies	22% ± 5%	Explore
GABAergic neuron	3 studies	21% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GDF11 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3075.12	2642 / 2642	100%	24.69	704 / 705
prostate	100%	1905.76	245 / 245	94%	17.00	473 / 502
ovary	100%	1592.91	180 / 180	91%	16.50	393 / 430
adrenal gland	99%	806.50	255 / 258	90%	12.76	208 / 230
thymus	100%	1065.89	651 / 653	87%	6.07	528 / 605
bladder	100%	1535.05	21 / 21	79%	6.17	397 / 504
lung	99%	986.53	573 / 578	77%	5.76	893 / 1155
skin	84%	698.85	1520 / 1809	89%	20.48	422 / 472
kidney	98%	762.84	87 / 89	74%	4.98	667 / 901
intestine	98%	1211.23	947 / 966	67%	4.17	355 / 527
uterus	100%	1734.40	170 / 170	64%	7.88	293 / 459
breast	97%	657.59	447 / 459	62%	3.38	689 / 1118
stomach	88%	590.31	316 / 359	69%	4.60	198 / 286
esophagus	90%	767.49	1302 / 1445	66%	4.19	121 / 183
pancreas	41%	169.85	133 / 328	74%	4.40	132 / 178
spleen	100%	1611.76	241 / 241	0%	0	0 / 0
adipose	99%	816.77	1193 / 1204	0%	0	0 / 0
heart	97%	1319.36	833 / 861	0%	0	0 / 0
blood vessel	88%	608.99	1181 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	86%	19.95	69 / 80
lymph node	0%	0	0 / 0	76%	3.57	22 / 29
tonsil	0%	0	0 / 0	56%	3.66	25 / 45
muscle	53%	259.58	424 / 803	0%	0	0 / 0
peripheral blood	51%	384.53	478 / 929	0%	0	0 / 0
liver	25%	91.85	57 / 226	13%	1.02	54 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007498	Biological process	mesoderm development
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0001657	Biological process	ureteric bud development
GO_0032924	Biological process	activin receptor signaling pathway
GO_0008283	Biological process	cell population proliferation
GO_0048593	Biological process	camera-type eye morphogenesis
GO_0001656	Biological process	metanephros development
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_1902870	Biological process	negative regulation of amacrine cell differentiation
GO_0072560	Biological process	type B pancreatic cell maturation
GO_0060395	Biological process	SMAD protein signal transduction
GO_0060021	Biological process	roof of mouth development
GO_0001501	Biological process	skeletal system development
GO_0007399	Biological process	nervous system development
GO_0035881	Biological process	amacrine cell differentiation
GO_0021512	Biological process	spinal cord anterior/posterior patterning
GO_0005615	Cellular component	extracellular space
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0008083	Molecular function	growth factor activity
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

Gene name	GDF11
Protein name	Growth differentiation factor 11 Growth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11)
Synonyms	BMP11
Description	FUNCTION: Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development . Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 . .
Accessions	O95390 H0YI30 ENST00000257868.10 ENST00000546799.1

GDF11 report