GDE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0006580Biological processethanolamine metabolic process
GO_0046475Biological processglycerophospholipid catabolic process
GO_0070291Biological processN-acylethanolamine metabolic process
GO_0006629Biological processlipid metabolic process
GO_0005886Cellular componentplasma membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0016020Cellular componentmembrane
GO_0008889Molecular functionglycerophosphodiester phosphodiesterase activity
GO_0004622Molecular functionlysophospholipase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0047395Molecular functionglycerophosphoinositol glycerophosphodiesterase activity

IV. Literature review

[source]
Gene nameGDE1
Protein nameGlycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein)
Glycerophosphodiester phosphodiesterase 1
SynonymsMIR16
DescriptionFUNCTION: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity). .

AccessionsENST00000353258.8
H3BU22
ENST00000564172.1
ENST00000569899.5
ENST00000569773.1
H3BNA5
H3BRL5
Q9NZC3