GCSAM report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GCSAM at tissue level.

III. Associated gene sets

GO_0050855Biological processregulation of B cell receptor signaling pathway
GO_2000402Biological processnegative regulation of lymphocyte migration
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0045159Molecular functionmyosin II binding
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameGCSAM
Protein nameGerminal center associated signaling and motility (Germinal center-associated-signaling and motility protein)
Germinal center-associated signaling and motility protein (Germinal center B-cell-expressed transcript 2 protein) (Germinal center-associated lymphoma protein) (hGAL)
SynonymsGAL
GCET2
DescriptionFUNCTION: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. .

AccessionsC9IY73
ENST00000495418.5
Q8N6F7
ENST00000460387.6 [Q8N6F7-3]
ENST00000487901.1
ENST00000646361.1
ENST00000643065.1 [Q8N6F7-2]
C9JY41
ENST00000645314.1
F2Z3F7
ENST00000470085.5
ENST00000308910.9 [Q8N6F7-1]
ENST00000488580.5
ENST00000484193.5 [Q8N6F7-2]
ENST00000644247.1 [Q8N6F7-3]
ENST00000646639.2 [Q8N6F7-1]
ENST00000643636.1
ENST00000647520.1