GCH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006729Biological processtetrahydrobiopterin biosynthetic process
GO_0008217Biological processregulation of blood pressure
GO_2000773Biological processnegative regulation of cellular senescence
GO_0014916Biological processregulation of lung blood pressure
GO_0034612Biological processresponse to tumor necrosis factor
GO_0050884Biological processneuromuscular process controlling posture
GO_0034341Biological processresponse to type II interferon
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0065003Biological processprotein-containing complex assembly
GO_2000121Biological processregulation of removal of superoxide radicals
GO_0042416Biological processdopamine biosynthetic process
GO_0042559Biological processpteridine-containing compound biosynthetic process
GO_0051066Biological processdihydrobiopterin metabolic process
GO_0045776Biological processnegative regulation of blood pressure
GO_0046654Biological processtetrahydrofolate biosynthetic process
GO_0048265Biological processresponse to pain
GO_0006809Biological processnitric oxide biosynthetic process
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0042311Biological processvasodilation
GO_0010460Biological processpositive regulation of heart rate
GO_0032496Biological processresponse to lipopolysaccharide
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0044306Cellular componentneuron projection terminus
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0003934Molecular functionGTP cyclohydrolase I activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0030742Molecular functionGTP-dependent protein binding
GO_0042802Molecular functionidentical protein binding
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0005525Molecular functionGTP binding
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGCH1
Protein nameGTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)
SynonymsDYT5
GCH
DescriptionFUNCTION: Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. .

AccessionsENST00000491895.7 [P30793-1]
ENST00000543643.6 [P30793-4]
ENST00000395514.5 [P30793-1]
P30793
ENST00000536224.2 [P30793-2]