GBP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GBP3 at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0051715Biological processcytolysis in another organism
GO_0140639Biological processpositive regulation of pyroptotic inflammatory response
GO_0051607Biological processdefense response to virus
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0071347Biological processcellular response to interleukin-1
GO_0071346Biological processcellular response to type II interferon
GO_0042742Biological processdefense response to bacterium
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005525Molecular functionGTP binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameGBP3
Protein nameGuanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3)
Guanylate binding protein 3
SynonymshCG_2039462
DescriptionFUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens . Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Exhibits antiviral activity against influenza virus . .; FUNCTION: [Isoform 2]: Shows the most prominent antiviral activity in epithelial cells. .

AccessionsH3BPH2
ENST00000445969.1
F6X827
ENST00000568006.1
H3BP53
ENST00000461384.6
Q5T8M0
ENST00000564665.1
ENST00000493594.6
ENST00000489444.6
H3BNS1
H3BRX6
Q9H0R5
ENST00000235878.5
F6SPX6
ENST00000370481.9 [Q9H0R5-1]