GAS8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_1904526Biological processregulation of microtubule binding
GO_0007368Biological processdetermination of left/right symmetry
GO_0051649Biological processestablishment of localization in cell
GO_0003351Biological processepithelial cilium movement involved in extracellular fluid movement
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0030317Biological processflagellated sperm motility
GO_0035082Biological processaxoneme assembly
GO_0007420Biological processbrain development
GO_0060294Biological processcilium movement involved in cell motility
GO_0008104Biological processprotein localization
GO_1903566Biological processpositive regulation of protein localization to cilium
GO_0036126Cellular componentsperm flagellum
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0031514Cellular componentmotile cilium
GO_0005794Cellular componentGolgi apparatus
GO_0005930Cellular componentaxoneme
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0036064Cellular componentciliary basal body
GO_0031267Molecular functionsmall GTPase binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameGAS8
Protein nameGrowth arrest specific 8
Dynein regulatory complex subunit 4 (Growth arrest-specific protein 8)
Dynein regulatory complex subunit 4 (Growth arrest-specific protein 11) (GAS-11) (Growth arrest-specific protein 8) (GAS-8)
SynonymsDRC4
GAS11
DescriptionFUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning . Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity). .

AccessionsENST00000566266.5
A0A087WZT7
ENST00000536122.7 [O95995-2]
ENST00000561675.1
ENST00000620723.4
H3BUA7
ENST00000565062.5
ENST00000268699.9 [O95995-1]
H3BP65
O95995
ENST00000564392.5
H3BME0
H3BQT7