GAN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007010Biological processcytoskeleton organization
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameGAN
Protein nameGigaxonin
Epididymis secretory sperm binding protein (Giant axonal neuropathy (Gigaxonin)) (Gigaxonin isoform 1)
Gigaxonin (Kelch-like protein 16)
SynonymshCG_22116
KLHL16
GAN1
DescriptionFUNCTION: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. .

AccessionsENST00000648994.2
A0A3B3ITY2
Q9H2C0
ENST00000650388.1
A0A0S2Z4W2
ENST00000648349.2
A0A0S2Z5G5