FZR1 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	22% ± 6%	Explore
GABAergic neuron	3 studies	25% ± 9%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZR1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3134.13	1445 / 1445	100%	38.29	183 / 183
liver	100%	2541.11	226 / 226	100%	21.71	406 / 406
ovary	100%	4302.82	180 / 180	100%	22.86	430 / 430
pancreas	100%	1898.67	328 / 328	100%	33.54	178 / 178
thymus	100%	5191.62	653 / 653	100%	31.70	605 / 605
uterus	100%	4173.64	170 / 170	100%	39.68	459 / 459
brain	100%	4002.13	2636 / 2642	100%	43.60	705 / 705
stomach	100%	2402.59	359 / 359	100%	30.03	285 / 286
intestine	100%	3282.21	966 / 966	100%	31.63	525 / 527
adrenal gland	100%	4631.95	258 / 258	100%	40.26	229 / 230
breast	100%	3353.32	459 / 459	100%	30.89	1113 / 1118
prostate	100%	4159.09	245 / 245	99%	32.87	499 / 502
skin	100%	4136.49	1809 / 1809	99%	32.30	469 / 472
kidney	100%	3283.18	89 / 89	99%	21.72	895 / 901
bladder	100%	3160.29	21 / 21	99%	32.54	500 / 504
lung	100%	2976.12	577 / 578	99%	28.67	1144 / 1155
adipose	100%	2540.55	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	36.26	80 / 80
lymph node	0%	0	0 / 0	100%	31.15	29 / 29
spleen	100%	3736.93	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	44.62	45 / 45
ureter	0%	0	0 / 0	100%	21.41	1 / 1
blood vessel	100%	3001.29	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	2836.95	927 / 929	0%	0	0 / 0
muscle	100%	1918.52	799 / 803	0%	0	0 / 0
heart	98%	1685.09	843 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006281	Biological process	DNA repair
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0051445	Biological process	regulation of meiotic cell cycle
GO_0051301	Biological process	cell division
GO_0007095	Biological process	mitotic G2 DNA damage checkpoint signaling
GO_1904668	Biological process	positive regulation of ubiquitin protein ligase activity
GO_0031145	Biological process	anaphase-promoting complex-dependent catabolic process
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0040020	Biological process	regulation of meiotic nuclear division
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0070306	Biological process	lens fiber cell differentiation
GO_1905786	Biological process	positive regulation of anaphase-promoting complex-dependent catabolic process
GO_2000773	Biological process	negative regulation of cellular senescence
GO_0005680	Cellular component	anaphase-promoting complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_1990757	Molecular function	ubiquitin ligase activator activity
GO_0005515	Molecular function	protein binding
GO_0010997	Molecular function	anaphase-promoting complex binding

Gene name	FZR1
Protein name	Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) Fizzy and cell division cycle 20 related 1
Synonyms	FYR FZR KIAA1242 CDH1
Description	FUNCTION: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) . .
Accessions	Q9UM11 ENST00000395095.7 [Q9UM11-1] ENST00000313639.8 [Q9UM11-3] K7EQT1 ENST00000591290.5 ENST00000441788.7 [Q9UM11-2] ENST00000652521.1 [Q9UM11-2]

FZR1 report