FUT10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097150Biological processneuronal stem cell population maintenance
GO_0009312Biological processoligosaccharide biosynthetic process
GO_0030097Biological processhemopoiesis
GO_0036445Biological processneuronal stem cell division
GO_0036065Biological processfucosylation
GO_0042355Biological processL-fucose catabolic process
GO_0006605Biological processprotein targeting
GO_0036071Biological processN-glycan fucosylation
GO_0042060Biological processwound healing
GO_0006457Biological processprotein folding
GO_0009566Biological processfertilization
GO_0097402Biological processneuroblast migration
GO_0007399Biological processnervous system development
GO_0021799Biological processcerebral cortex radially oriented cell migration
GO_0006486Biological processprotein glycosylation
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0046920Molecular functionalpha-(1->3)-fucosyltransferase activity

IV. Literature review

[source]
Gene nameFUT10
Protein nameAlpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)
Synonyms
DescriptionFUNCTION: Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. Postulated to generate core alpha(1->3)-fucose epitope within the chitobiose unit of biantennary N-glycans, providing for a recognition signal to reorient aberrantly folded glycoproteins for degradation . Involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity). .; FUNCTION: [Isoform 1]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. .; FUNCTION: [Isoform 4]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. .; FUNCTION: [Isoform 5]: Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. Does not fucosylate GlcNAc within type 2 lactosamine unit. .

AccessionsENST00000524021.1 [Q6P4F1-6]
Q6P4F1
ENST00000327671.10 [Q6P4F1-1]
ENST00000518672.5 [Q6P4F1-6]