FSTL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030510Biological processregulation of BMP signaling pathway
GO_0007275Biological processmulticellular organism development
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0032926Biological processnegative regulation of activin receptor signaling pathway
GO_0090101Biological processnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO_0030154Biological processcell differentiation
GO_0001503Biological processossification
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005654Cellular componentnucleoplasm
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005634Cellular componentnucleus
GO_0001968Molecular functionfibronectin binding
GO_0048185Molecular functionactivin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFSTL3
Protein nameFollistatin-related protein 3 (Follistatin-like protein 3) (Follistatin-related gene protein)
Follistatin like 3
SynonymsFLRG
UNQ674/PRO1308
DescriptionFUNCTION: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. .

AccessionsA0A087WTD3
ENST00000591573.1
ENST00000605925.3
ENST00000588773.5
K7EM71
ENST00000166139.9 [O95633-1]
O95633
A0A087X1Q2
ENST00000592947.5
ENST00000589185.2