FOXN1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXN1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXN1 at tissue level.

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0030216Biological processkeratinocyte differentiation
GO_0008544Biological processepidermis development
GO_0035878Biological processnail development
GO_0009887Biological processanimal organ morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0097535Biological processlymphoid lineage cell migration into thymus
GO_0051798Biological processpositive regulation of hair follicle development
GO_0097536Biological processthymus epithelium morphogenesis
GO_0001942Biological processhair follicle development
GO_0002360Biological processT cell lineage commitment
GO_0048514Biological processblood vessel morphogenesis
GO_1902232Biological processregulation of positive thymic T cell selection
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006952Biological processdefense response
GO_0030858Biological processpositive regulation of epithelial cell differentiation
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFOXN1
Protein nameForkhead box protein N1 (Winged-helix transcription factor nude)
Forkhead box protein N1
SynonymsWHN
RONU
DescriptionFUNCTION: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny . .

AccessionsO15353
ENST00000226247.2
ENST00000577936.2
ENST00000577936.1
ENST00000579795.6
J3KRT9