FOXI3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FOXI3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FOXI3 at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0060037Biological processpharyngeal system development
GO_1905040Biological processotic placode development
GO_0030154Biological processcell differentiation
GO_0009957Biological processepidermal cell fate specification
GO_0048538Biological processthymus development
GO_0001942Biological processhair follicle development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0060017Biological processparathyroid gland development
GO_0009653Biological processanatomical structure morphogenesis
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameFOXI3
Protein nameForkhead box protein I3
Synonyms
DescriptionFUNCTION: Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development . May act as a pioneer transcription factor during pharyngeal arch development (By similarity). Required for epithelial cell differentiation within the epidermis (By similarity). Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (By similarity). Required for hair follicle stem cell specification (By similarity). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (By similarity). .

AccessionsA8MTJ6
ENST00000428390.3