FMO5 | OmnibusX

Name	Number of supported studies	Average coverage
brain	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	7480.19	226 / 226	97%	116.60	395 / 406
prostate	95%	620.75	232 / 245	92%	16.55	463 / 502
pancreas	99%	2108.60	326 / 328	85%	12.27	152 / 178
stomach	92%	9752.28	332 / 359	81%	9.67	232 / 286
intestine	90%	1342.00	866 / 966	83%	9.54	435 / 527
breast	95%	875.28	436 / 459	74%	13.52	825 / 1118
kidney	99%	713.21	88 / 89	58%	4.47	519 / 901
lung	91%	2354.28	524 / 578	64%	18.59	743 / 1155
thymus	90%	318.64	585 / 653	45%	2.92	275 / 605
bladder	81%	370.05	17 / 21	53%	5.43	267 / 504
brain	69%	192.63	1819 / 2642	48%	2.21	335 / 705
adrenal gland	95%	689.14	246 / 258	19%	1.17	43 / 230
uterus	92%	296.98	156 / 170	21%	1.45	97 / 459
skin	84%	1001.30	1522 / 1809	26%	1.70	124 / 472
ovary	95%	341.12	171 / 180	7%	0.27	29 / 430
spleen	98%	411.05	237 / 241	0%	0	0 / 0
esophagus	48%	117.53	693 / 1445	49%	7.71	89 / 183
adipose	89%	332.20	1072 / 1204	0%	0	0 / 0
blood vessel	77%	220.76	1032 / 1335	0%	0	0 / 0
heart	41%	145.03	356 / 861	0%	0	0 / 0
peripheral blood	16%	33.60	146 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.39	2 / 29
muscle	6%	12.18	51 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.09	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0090181	Biological process	regulation of cholesterol metabolic process
GO_0070995	Biological process	NADPH oxidation
GO_0006805	Biological process	xenobiotic metabolic process
GO_0006629	Biological process	lipid metabolic process
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0047822	Molecular function	hypotaurine dehydrogenase activity
GO_0050661	Molecular function	NADP binding
GO_0004499	Molecular function	N,N-dimethylaniline monooxygenase activity
GO_0004497	Molecular function	monooxygenase activity
GO_0106294	Molecular function	NADPH oxidase H202-forming activity
GO_0004031	Molecular function	aldehyde oxidase activity
GO_0050660	Molecular function	flavin adenine dinucleotide binding

Gene name	FMO5
Protein name	Flavin containing dimethylaniline monoxygenase 5 Flavin-containing monooxygenase (EC 1.-.-.-) Flavin-containing monooxygenase 5 (FMO 5) (Baeyer-Villiger monooxygenase 1) (hBVMO1) (EC 1.14.13.-) (Dimethylaniline monooxygenase [N-oxide-forming] 5) (EC 1.14.13.8) (Dimethylaniline oxidase 5) (NADPH oxidase) (EC 1.6.3.1)
Synonyms	hCG_1981889
Description	FUNCTION: Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters . Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive . In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) . Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline . Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity . Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). .
Accessions	Q9HA79 ENST00000527849.5 E9PJF3 ENST00000578284.5 [P49326-3] P49326 ENST00000533848.2 ENST00000441068.6 [P49326-3] ENST00000254090.9 [P49326-1] ENST00000369272.7 [P49326-2] E9PQ84 E9PP51 ENST00000533174.5

FMO5 report