FKBP6 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of FKBP6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	95%	7.39	230 / 241	0%	0	0 / 0
adrenal gland	92%	4.50	237 / 258	0%	0	0 / 230
prostate	86%	7.69	211 / 245	0%	0	0 / 502
ovary	85%	4.35	153 / 180	0%	0.00	1 / 430
brain	85%	4.44	2241 / 2642	0%	0	0 / 705
lung	84%	6.03	485 / 578	0%	0.00	2 / 1155
adipose	84%	4.15	1006 / 1204	0%	0	0 / 0
breast	83%	5.63	380 / 459	0%	0.00	1 / 1118
thymus	82%	4.63	534 / 653	0%	0.00	2 / 605
uterus	81%	3.76	138 / 170	0%	0.00	1 / 459
bladder	81%	2.67	17 / 21	0%	0	0 / 504
stomach	78%	3.02	280 / 359	2%	0.02	5 / 286
liver	78%	3.12	177 / 226	0%	0	0 / 406
pancreas	78%	2.97	256 / 328	0%	0	0 / 178
intestine	75%	3.06	728 / 966	0%	0.00	1 / 527
blood vessel	74%	2.44	989 / 1335	0%	0	0 / 0
esophagus	70%	2.74	1015 / 1445	1%	0.01	1 / 183
skin	69%	2.65	1246 / 1809	1%	0.01	4 / 472
kidney	69%	3.56	61 / 89	0%	0.00	1 / 901
muscle	60%	2.57	483 / 803	0%	0	0 / 0
peripheral blood	55%	1.42	514 / 929	0%	0	0 / 0
heart	53%	1.34	455 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006457	Biological process	protein folding
GO_0051321	Biological process	meiotic cell cycle
GO_0141007	Biological process	siRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0007283	Biological process	spermatogenesis
GO_0045070	Biological process	positive regulation of viral genome replication
GO_0030154	Biological process	cell differentiation
GO_0031047	Biological process	regulatory ncRNA-mediated gene silencing
GO_0034587	Biological process	piRNA processing
GO_0000795	Cellular component	synaptonemal complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005528	Molecular function	FK506 binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity
GO_0051879	Molecular function	Hsp90 protein binding

Gene name	FKBP6
Protein name	Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) peptidylprolyl isomerase (EC 5.2.1.8)
Synonyms	FKBP36
Description	FUNCTION: Has an essential role in spermatogenesis . It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). .
Accessions	O75344 ENST00000445032.5 ENST00000429879.5 ENST00000413573.6 [O75344-3] ENST00000431982.6 [O75344-2] ENST00000648538.1 ENST00000442793.5 C9JM01 F8WD36 F8WD38 A0A3B3IST2 ENST00000252037.5 [O75344-1]

FKBP6 report