FIGN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051301Biological processcell division
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0016363Cellular componentnuclear matrix
GO_0005813Cellular componentcentrosome
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0008568Molecular functionmicrotubule severing ATPase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameFIGN
Protein nameFidgetin
Fidgetin, microtubule severing factor
Synonyms
DescriptionFUNCTION: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. .

AccessionsB8ZZS6
ENST00000409634.5
ENST00000333129.4
Q5HY92