FBXO5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FBXO5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXO5 at tissue level.

III. Associated gene sets

GO_0032876Biological processnegative regulation of DNA endoreduplication
GO_0016567Biological processprotein ubiquitination
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_1905322Biological processpositive regulation of mesenchymal stem cell migration
GO_2000773Biological processnegative regulation of cellular senescence
GO_0070169Biological processpositive regulation of biomineral tissue development
GO_0006974Biological processDNA damage response
GO_0007057Biological processspindle assembly involved in female meiosis I
GO_0051301Biological processcell division
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0001556Biological processoocyte maturation
GO_0045835Biological processnegative regulation of meiotic nuclear division
GO_0046785Biological processmicrotubule polymerization
GO_0016050Biological processvesicle organization
GO_0007346Biological processregulation of mitotic cell cycle
GO_1904667Biological processnegative regulation of ubiquitin protein ligase activity
GO_0045841Biological processnegative regulation of mitotic metaphase/anaphase transition
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0006275Biological processregulation of DNA replication
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0072687Cellular componentmeiotic spindle
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_1990948Molecular functionubiquitin ligase inhibitor activity
GO_0019901Molecular functionprotein kinase binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0010997Molecular functionanaphase-promoting complex binding
GO_0140678Molecular functionmolecular function inhibitor activity

IV. Literature review

[source]
Gene nameFBXO5
Protein nameF-box only protein 5 (Early mitotic inhibitor 1)
SynonymsEMI1
FBX5
DescriptionFUNCTION: Regulator of APC activity during mitotic and meiotic cell cycle . During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex . During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase . Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment . As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities . Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence . During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells . .

AccessionsQ9UKT4
ENST00000229758.8 [Q9UKT4-1]
ENST00000367241.3 [Q9UKT4-2]