FBXO22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006913Biological processnucleocytoplasmic transport
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0048742Biological processregulation of skeletal muscle fiber development
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0036211Biological processprotein modification process
GO_0000209Biological processprotein polyubiquitination
GO_0009267Biological processcellular response to starvation
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005829Cellular componentcytosol
GO_0030018Cellular componentZ disc
GO_0005634Cellular componentnucleus
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO22
Protein nameF-box only protein 22 (F-box protein FBX22p44)
F-box protein 22
SynonymsFBX22
DescriptionFUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. .

AccessionsENST00000453211.6 [Q8NEZ5-3]
ENST00000561885.1
H3BTR7
H3BUC1
ENST00000569749.5
ENST00000564220.1
ENST00000569054.5
H3BVA4
Q8NEZ5
ENST00000565036.5
H3BRE0
ENST00000569022.1 [Q8NEZ5-2]
ENST00000308275.8 [Q8NEZ5-1]
H3BTH6