I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 26% ± 4% | |
| glutamatergic neuron | 3 studies | 36% ± 5% | |
| transit amplifying cell | 3 studies | 32% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 26% ± 4% | |
| glutamatergic neuron | 3 studies | 36% ± 5% | |
| transit amplifying cell | 3 studies | 32% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 278.22 | 1443 / 1445 | 99% | 5.10 | 182 / 183 |
| breast | 100% | 445.82 | 459 / 459 | 97% | 3.94 | 1090 / 1118 |
| uterus | 100% | 451.35 | 170 / 170 | 95% | 4.05 | 438 / 459 |
| lung | 98% | 258.92 | 565 / 578 | 96% | 3.01 | 1114 / 1155 |
| bladder | 100% | 294.38 | 21 / 21 | 92% | 2.56 | 463 / 504 |
| intestine | 100% | 277.66 | 964 / 966 | 90% | 2.33 | 472 / 527 |
| thymus | 99% | 301.73 | 649 / 653 | 88% | 1.94 | 532 / 605 |
| stomach | 100% | 211.66 | 358 / 359 | 87% | 2.58 | 249 / 286 |
| prostate | 100% | 301.89 | 245 / 245 | 87% | 1.89 | 435 / 502 |
| brain | 96% | 223.84 | 2548 / 2642 | 90% | 2.01 | 633 / 705 |
| skin | 100% | 434.30 | 1806 / 1809 | 82% | 2.76 | 387 / 472 |
| ovary | 100% | 489.78 | 180 / 180 | 82% | 1.69 | 351 / 430 |
| pancreas | 95% | 143.91 | 312 / 328 | 86% | 1.76 | 153 / 178 |
| kidney | 100% | 213.17 | 89 / 89 | 77% | 1.67 | 698 / 901 |
| adrenal gland | 100% | 312.65 | 258 / 258 | 77% | 1.59 | 177 / 230 |
| liver | 94% | 119.95 | 213 / 226 | 47% | 0.80 | 191 / 406 |
| spleen | 100% | 399.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 407.12 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 336.67 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 223.68 | 791 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 4.44 | 44 / 45 |
| heart | 95% | 201.02 | 820 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 3.35 | 27 / 29 |
| peripheral blood | 44% | 308.07 | 407 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 38% | 0.81 | 30 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032508 | Biological process | DNA duplex unwinding |
| GO_0036297 | Biological process | interstrand cross-link repair |
| GO_0045003 | Biological process | double-strand break repair via synthesis-dependent strand annealing |
| GO_1902527 | Biological process | positive regulation of protein monoubiquitination |
| GO_0031297 | Biological process | replication fork processing |
| GO_0000712 | Biological process | resolution of meiotic recombination intermediates |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0043240 | Cellular component | Fanconi anaemia nuclear complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0071821 | Cellular component | FANCM-MHF complex |
| GO_0000785 | Cellular component | chromatin |
| GO_0003724 | Molecular function | RNA helicase activity |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0009378 | Molecular function | four-way junction helicase activity |
| GO_0000400 | Molecular function | four-way junction DNA binding |
| GO_0004518 | Molecular function | nuclease activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0043138 | Molecular function | 3'-5' DNA helicase activity |
| Gene name | FANCM |
| Protein name | Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) FA complementation group M FA complementation group M (Fanconi anemia, complementation group M, isoform CRA_c) |
| Synonyms | hCG_2039373 KIAA1596 |
| Description | FUNCTION: DNA-dependent ATPase component of the Fanconi anemia (FA) core complex . Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage . In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates . Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX . In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates . In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA . . |
| Accessions | H0YJS3 H0YJ45 A0A8Q3SIU9 ENST00000696679.1 ENST00000696659.1 ENST00000696681.1 ENST00000696643.1 A0A8Q3SIQ3 A0A8Q3WLH3 ENST00000267430.10 [Q8IYD8-1] A0A8Q3WLG3 A0A8Q3WMK3 ENST00000696685.1 A0A8Q3WMJ4 ENST00000696647.1 H0YJ14 ENST00000557110.2 ENST00000696664.1 ENST00000696646.1 H0YJN7 ENST00000696677.1 A0A8Q3SIT9 A0A8Q3WLH2 ENST00000542564.6 [Q8IYD8-3] ENST00000696683.1 A0A8Q3WLH1 A0A8Q3WLG5 A0A8Q3SJG0 A0A8Q3WLZ4 ENST00000696648.1 ENST00000556250.6 ENST00000556036.6 [Q8IYD8-2] ENST00000696649.1 ENST00000696675.1 ENST00000696642.1 A0A8Q3WLE9 ENST00000696682.1 ENST00000696662.1 A0A8Q3SIU7 ENST00000554030.2 ENST00000555484.2 A0A8Q3WLE8 A0A8Q3SIZ4 A0A8Q3WLY4 Q8IYD8 ENST00000696657.1 ENST00000696663.1 ENST00000696665.1 A0A8Q3SJ05 ENST00000554809.6 ENST00000696680.1 A0A8Q3SIV0 A0A8Q3WLG0 ENST00000696641.1 ENST00000696676.1 ENST00000696684.1 A0A8Q3SIX9 |
