FANCD2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FANCD2 at tissue level.

III. Associated gene sets

GO_0097150Biological processneuronal stem cell population maintenance
GO_0036297Biological processinterstrand cross-link repair
GO_0010332Biological processresponse to gamma radiation
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0007276Biological processgamete generation
GO_0050727Biological processregulation of inflammatory response
GO_0034599Biological processcellular response to oxidative stress
GO_0045589Biological processregulation of regulatory T cell differentiation
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_2000348Biological processregulation of CD40 signaling pathway
GO_0048854Biological processbrain morphogenesis
GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_1990391Cellular componentDNA repair complex
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0070182Molecular functionDNA polymerase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFANCD2
Protein nameFA complementation group D2
Fanconi anemia group D2 protein (Protein FACD2)
SynonymsFACD
DescriptionFUNCTION: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching. .

AccessionsENST00000287647.7 [Q9BXW9-1]
ENST00000675286.1 [Q9BXW9-2]
ENST00000625535.1
ENST00000431693.1 [Q9BXW9-4]
A0A6Q8PFY3
ENST00000435522.5
H7BZJ7
Q9BXW9
ENST00000419585.5 [Q9BXW9-2]
ENST00000421731.5
ENST00000682647.1
F8WE37
ENST00000676013.1