FADS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043651Biological processlinoleic acid metabolic process
GO_0046456Biological processicosanoid biosynthetic process
GO_0009267Biological processcellular response to starvation
GO_0007267Biological processcell-cell signaling
GO_0008654Biological processphospholipid biosynthetic process
GO_0045595Biological processregulation of cell differentiation
GO_0036109Biological processalpha-linolenic acid metabolic process
GO_0006355Biological processregulation of DNA-templated transcription
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0045485Molecular functionomega-6 fatty acid desaturase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0016717Molecular functionoxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO_0000248Molecular functionC-5 sterol desaturase activity
GO_0062076Molecular functionacyl-CoA delta5-desaturase activity
GO_0016213Molecular functionlinoleoyl-CoA desaturase activity

IV. Literature review

[source]
Gene nameFADS1
Protein nameAcyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1)
Fatty acid desaturase 1
SynonymshCG_40849
FADSD5
DescriptionFUNCTION: [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively . As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). .; FUNCTION: [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. .

AccessionsO60427
ENST00000545245.5
ENST00000542506.5 [O60427-2]
F5GWE3
A0A0A0MR51
I3ZNN6
ENST00000424501.5
F5H5X5
I3ZNS6
F5H2H3
ENST00000473263.1
ENST00000539999.1
ENST00000448607.1
C9JJB3
ENST00000536991.5
F5H852
ENST00000544696.5
I3ZNL9
H7C2V0
ENST00000545405.5
H0YB97
F5GYH4
ENST00000433932.5 [O60427-2]
I3ZNT3
ENST00000540767.5
ENST00000350997.12
I3ZNS3
ENST00000421879.5
F5H8G5
F5H1Q7
F5H3P6
I3ZNE3
ENST00000460649.5
I3ZNE2
ENST00000539419.5
I3ZNH3
F5H3U5
ENST00000491310.5
I3ZNL2
F5H0Y2
C9J425
ENST00000466716.5
I3ZNS1
F5H2R9
ENST00000544309.5