Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 18 studies | 33% ± 14% | |
| endothelial cell of lymphatic vessel | 18 studies | 29% ± 10% | |
| endothelial cell of artery | 9 studies | 39% ± 16% | |
| capillary endothelial cell | 6 studies | 34% ± 19% | |
| vein endothelial cell | 6 studies | 26% ± 11% | |
| endothelial cell of vascular tree | 6 studies | 28% ± 10% | |
| glomerular endothelial cell | 4 studies | 54% ± 7% | |
| endothelial cell of sinusoid | 3 studies | 37% ± 14% |
Insufficient scRNA-seq data for expression of F8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 100% | 2343.31 | 258 / 258 | 99% | 8.00 | 227 / 230 |
| kidney | 100% | 1831.90 | 89 / 89 | 98% | 21.02 | 886 / 901 |
| breast | 100% | 3593.95 | 457 / 459 | 99% | 6.45 | 1104 / 1118 |
| thymus | 99% | 2213.99 | 648 / 653 | 98% | 5.32 | 594 / 605 |
| prostate | 98% | 1554.55 | 239 / 245 | 98% | 5.62 | 494 / 502 |
| ovary | 99% | 2759.05 | 179 / 180 | 95% | 3.00 | 408 / 430 |
| lung | 98% | 2979.21 | 567 / 578 | 94% | 4.09 | 1084 / 1155 |
| uterus | 98% | 2313.94 | 167 / 170 | 87% | 2.70 | 400 / 459 |
| brain | 81% | 932.72 | 2147 / 2642 | 100% | 6.60 | 703 / 705 |
| bladder | 100% | 1391.71 | 21 / 21 | 67% | 1.80 | 337 / 504 |
| pancreas | 73% | 1009.07 | 239 / 328 | 92% | 2.63 | 164 / 178 |
| esophagus | 71% | 1432.42 | 1021 / 1445 | 87% | 2.43 | 159 / 183 |
| liver | 70% | 764.67 | 159 / 226 | 86% | 3.24 | 348 / 406 |
| skin | 56% | 397.68 | 1015 / 1809 | 93% | 3.93 | 437 / 472 |
| intestine | 77% | 1199.15 | 741 / 966 | 58% | 1.33 | 308 / 527 |
| stomach | 64% | 739.20 | 228 / 359 | 71% | 1.92 | 202 / 286 |
| adipose | 100% | 4836.22 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 4983.44 | 861 / 861 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2084.43 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2806.67 | 241 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 4.62 | 78 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 2.31 | 25 / 29 |
| blood vessel | 86% | 1140.97 | 1149 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 2.63 | 38 / 45 |
| peripheral blood | 29% | 178.30 | 265 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007597 | Biological process | blood coagulation, intrinsic pathway |
| GO_0006953 | Biological process | acute-phase response |
| GO_0007596 | Biological process | blood coagulation |
| GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030134 | Cellular component | COPII-coated ER to Golgi transport vesicle |
| GO_0016491 | Molecular function | oxidoreductase activity |
| GO_0005507 | Molecular function | copper ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | F8 |
| Protein name | Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain] Coagulation factor VIII Truncated coagulation factor VIII Factor VIII Factor FVIII |
| Synonyms | F8C |
| Description | FUNCTION: Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. |
| Accessions | F2WWL4 ENST00000453950.1 Q003V0 Q003V6 A0A2G4 A5JQJ9 E3VWA2 A0A2G3 F8UV73 A6NAE8 A0FJ20 A0A224A9M5 Q06DL6 A0A2G5 A0A224A1P2 Q06DL9 A0A2G6 A6NAF0 ENST00000423959.5 Q003V2 Q003V5 Q06DL8 A6NAE6 Q003V1 Q003V3 A0A2G9 A0FJ18 A0FJ19 Q003U9 A6NAE5 A5JQJ8 ENST00000330287.10 [P00451-2] A6NAE9 E3VWA5 A0A2G8 A0A2R8Y7J7 A5JQJ6 ENST00000360256.9 [P00451-1] Q003V8 Q003V4 Q003W0 B1B0G9 P00451 A0A2G2 A5JQJ5 E3VWA3 E3VWA4 B1B0G8 E3VWA6 Q003W2 A6NAF3 ENST00000647125.1 Q2VF45 ENST00000644698.1 G8GEI5 D5H408 A6NAF1 Q06DL7 Q003V7 A5JQJ7 Q003V9 A0A2R8Y707 |
