EXO1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EXO1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXO1 at tissue level.

III. Associated gene sets

GO_0090656Biological processt-circle formation
GO_0006281Biological processDNA repair
GO_0110025Biological processDNA strand resection involved in replication fork processing
GO_0051321Biological processmeiotic cell cycle
GO_0006310Biological processDNA recombination
GO_0045190Biological processisotype switching
GO_0016446Biological processsomatic hypermutation of immunoglobulin genes
GO_0006298Biological processmismatch repair
GO_0002455Biological processhumoral immune response mediated by circulating immunoglobulin
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004527Molecular functionexonuclease activity
GO_0008409Molecular function5'-3' exonuclease activity
GO_0051908Molecular functiondouble-stranded DNA 5'-3' DNA exonuclease activity
GO_0003682Molecular functionchromatin binding
GO_0035312Molecular function5'-3' DNA exonuclease activity
GO_0004523Molecular functionRNA-DNA hybrid ribonuclease activity
GO_0017108Molecular function5'-flap endonuclease activity
GO_0048256Molecular functionflap endonuclease activity
GO_0046872Molecular functionmetal ion binding
GO_0045145Molecular functionsingle-stranded DNA 5'-3' DNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXO1
Protein nameExonuclease 1
Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)
Exonuclease 1 (EC 3.1.-.-)
SynonymsHEX1
EXOI
DescriptionFUNCTION: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. .

FUNCTION: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair. .

FUNCTION: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair. .

FUNCTION: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair. .

FUNCTION: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair. .

AccessionsQ5T397
E5RGY3
ENST00000521202.2
Q5T399
ENST00000348581.9 [Q9UQ84-1]
ENST00000423131.5
ENST00000523590.5
ENST00000518483.5 [Q9UQ84-4]
Q9UQ84
Q5T398
E5RHK1
ENST00000366548.8 [Q9UQ84-1]
ENST00000519225.5
H0YAZ2
ENST00000450748.1
ENST00000437497.5