EXD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090304Biological processnucleic acid metabolic process
GO_0006302Biological processdouble-strand break repair
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0000729Biological processDNA double-strand break processing
GO_0031297Biological processreplication fork processing
GO_0005739Cellular componentmitochondrion
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0090734Cellular componentsite of DNA damage
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0003676Molecular functionnucleic acid binding
GO_0008310Molecular functionsingle-stranded DNA 3'-5' DNA exonuclease activity
GO_0008296Molecular function3'-5'-DNA exonuclease activity
GO_0000287Molecular functionmagnesium ion binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0030145Molecular functionmanganese ion binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXD2
Protein nameExonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (3'-5' exoribonuclease EXD2) (EC 3.1.13.-) (Exonuclease 3'-5' domain-like-containing protein 2)
Exonuclease 3'-5' domain containing 2
Alternative protein EXD2
SynonymsC14orf114
EXDL2
DescriptionFUNCTION: Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor . In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) . Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation . Also involved in the response to DNA damage . Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination . Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks . Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation . .

AccessionsA0A8I5KSH7
ENST00000409675.5 [Q9NVH0-2]
ENST00000409242.5 [Q9NVH0-2]
ENST00000413191.1
ENST00000492815.5
ENST00000685843.1 [Q9NVH0-1]
ENST00000409949.5 [Q9NVH0-2]
Q9NVH0
ENST00000312994.9 [Q9NVH0-1]
C9JLF4
L8EA17
ENST00000409014.5 [Q9NVH0-2]
ENST00000409018.7 [Q9NVH0-1]