EXD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EXD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXD1 at tissue level.

III. Associated gene sets

GO_0034587Biological processpiRNA processing
GO_0051321Biological processmeiotic cell cycle
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_1990923Cellular componentPET complex
GO_0043186Cellular componentP granule
GO_0042803Molecular functionprotein homodimerization activity
GO_0005515Molecular functionprotein binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEXD1
Protein nameExonuclease 3'-5' domain containing 1
piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1)
SynonymsEXDL1
DescriptionFUNCTION: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity). .

AccessionsH0YK66
ENST00000458580.7 [Q8NHP7-3]
ENST00000558396.1
Q8NHP7
ENST00000314992.9 [Q8NHP7-1]