ESRP2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ESRP2 at tissue level.

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0043484Biological processregulation of RNA splicing
GO_0060441Biological processepithelial tube branching involved in lung morphogenesis
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0060445Biological processbranching involved in salivary gland morphogenesis
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameESRP2
Protein nameEpithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B)
Epithelial splicing regulatory protein 2
SynonymsRBM35B
PP7059
DescriptionFUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. .

AccessionsENST00000566774.1
A0A0A1TTP8
J3QKU3
J3QQJ9
ENST00000565858.5 [Q9H6T0-1]
A0A0A1TE42
ENST00000564382.5
Q9H6T0
J3KRF2
ENST00000473183.7 [Q9H6T0-2]
ENST00000562724.1