ESRP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042669Biological processregulation of inner ear auditory receptor cell fate specification
GO_0043484Biological processregulation of RNA splicing
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameESRP1
Protein nameEpithelial splicing regulatory protein 1 (RNA-binding motif protein 35A) (RNA-binding protein 35A)
Epithelial splicing regulatory protein 1
SynonymsRBM35A
DescriptionFUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 . Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). .

AccessionsENST00000454170.7
ENST00000519505.5
H0YBR2
ENST00000358397.9 [Q6NXG1-3]
A0A2U3TZN9
E5RI26
H0YBB3
ENST00000423620.6 [Q6NXG1-5]
ENST00000433389.8 [Q6NXG1-1]
ENST00000517610.1
Q6NXG1
ENST00000522756.6
ENST00000646773.1 [Q6NXG1-2]