ESPN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051017Biological processactin filament bundle assembly
GO_0007605Biological processsensory perception of sound
GO_0030034Biological processmicrovillar actin bundle assembly
GO_0005903Cellular componentbrush border
GO_0005902Cellular componentmicrovillus
GO_0032420Cellular componentstereocilium
GO_0031941Cellular componentfilamentous actin
GO_0032426Cellular componentstereocilium tip
GO_0005737Cellular componentcytoplasm
GO_0051015Molecular functionactin filament binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameESPN
Protein nameEspin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein)
Espin
SynonymsLP2654
DFNB36
DescriptionFUNCTION: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells . Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia (By similarity). Involved in the elongation of actin in stereocilia . In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation. .

AccessionsENST00000477679.2
ENST00000633239.1
A0A1B0GUS9
A0A0J9YW00
ENST00000475479.2
A0A0J9YWQ8
A0A2R8Y6D3
A0A1B0GUN9
ENST00000461727.6 [B1AK53-2]
Q5JYL1
A0A2R8Y7L7
ENST00000645284.1 [B1AK53-1]
ENST00000478323.1
ENST00000636644.1
B1AK53
ENST00000475228.6
A0A2R8YG57
K7EMB7
ENST00000434576.2
A0A0J9YY76
ENST00000632593.1
ENST00000632803.1
ENST00000636330.1
ENST00000418286.1
H0Y7L4