ERI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000460Biological processmaturation of 5.8S rRNA
GO_0071044Biological processhistone mRNA catabolic process
GO_0031125Biological processrRNA 3'-end processing
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0000467Biological processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO_0005730Cellular componentnucleolus
GO_0071204Cellular componenthistone pre-mRNA 3'end processing complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0071207Molecular functionhistone pre-mRNA stem-loop binding
GO_0008408Molecular function3'-5' exonuclease activity
GO_0019843Molecular functionrRNA binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameERI1
Protein name3'-5' exoribonuclease 1 (EC 3.1.-.-) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO)
Exoribonuclease 1
SynonymsTHEX1
3'EXO
DescriptionFUNCTION: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication . A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates . Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) . Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure . Able to bind other mRNAs . Required for 5.8S rRNA 3'-end processing (By similarity). Also binds to 5.8s ribosomal RNA (By similarity). Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs . In vitro, does not have sequence specificity . In vitro, has weak DNA exonuclease activity . In vitro, shows biphasic kinetics such that there is rapid hydrolysis of the last three unpaired RNA nucleotides in the 39 flanking sequence followed by a much slower cleavage through the stem that occurs over a longer incubation period in the order of hours . .

AccessionsENST00000250263.8
A0AA34QW13
ENST00000520332.6
ENST00000519292.5
A0AA34QVV0
Q8IV48
E5RJM3
ENST00000521844.1
E5RIV7
ENST00000520684.5
ENST00000518663.2
ENST00000522612.2
A0AA34QVX9