ERCC8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000012Biological processsingle strand break repair
GO_0000209Biological processprotein polyubiquitination
GO_0010165Biological processresponse to X-ray
GO_0090262Biological processregulation of transcription-coupled nucleotide-excision repair
GO_0006974Biological processDNA damage response
GO_0051865Biological processprotein autoubiquitination
GO_0009411Biological processresponse to UV
GO_0097680Biological processdouble-strand break repair via classical nonhomologous end joining
GO_0006979Biological processresponse to oxidative stress
GO_0006283Biological processtranscription-coupled nucleotide-excision repair
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0016363Cellular componentnuclear matrix
GO_0000109Cellular componentnucleotide-excision repair complex
GO_0005634Cellular componentnucleus
GO_0044877Molecular functionprotein-containing complex binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERCC8
Protein nameExcision repair cross-complementing rodent repair deficiency complementation group 8 isoform 1 (Excision repair cross-complementing rodent repair deficiency, complementation group 8, isoform CRA_a)
Excision repair cross-complementing rodent repair deficiency complementation group 8 isoform 3
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
ERCC excision repair 8, CSA ubiquitin ligase complex subunit (Excision repair cross-complementing rodent repair deficiency, complementation group 8, isoform CRA_c)
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA)
ERCC excision repair 8, CSA ubiquitin ligase complex subunit (cDNA FLJ32369 fis, clone PUAEN1000276, highly similar to DNA excision repair protein ERCC-8)
DNA excision repair protein ERCC-8
SynonymsCKN1
hCG_2003063
CSA
DescriptionFUNCTION: Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) . .

AccessionsA0A6Q8PFI5
ENST00000676185.1 [Q13216-1]
A0A804HIH7
A0A804HJN0
A0A804HJL3
ENST00000683052.1
ENST00000647431.2
A0A7I2PE23
G3XAG7
A0A2R8YD24
B3KPW7
A0A2R8Y5I1
ENST00000675452.2
ENST00000439176.6
ENST00000675229.1 [Q13216-2]
ENST00000682375.1
ENST00000647486
ENST00000647486.2 [Q13216-2]
ENST00000643708.1
ENST00000675042.2
ENST00000682217.1
Q13216
C9JNT2
ENST00000497892.6
A0A0S2Z3P2
ENST00000643034.1
ENST00000683460.1
ENST00000265038.10
A0A2R8YEZ3
A0A6Q8PH55
A0A0S2Z3L1
ENST00000675378.1
ENST00000381118.7