EPHX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090181Biological processregulation of cholesterol metabolic process
GO_0010628Biological processpositive regulation of gene expression
GO_0097176Biological processepoxide metabolic process
GO_0046839Biological processphospholipid dephosphorylation
GO_0046272Biological processstilbene catabolic process
GO_0016311Biological processdephosphorylation
GO_0009636Biological processresponse to toxic substance
GO_0042632Biological processcholesterol homeostasis
GO_0070062Cellular componentextracellular exosome
GO_0005777Cellular componentperoxisome
GO_0005829Cellular componentcytosol
GO_0005782Cellular componentperoxisomal matrix
GO_0042803Molecular functionprotein homodimerization activity
GO_0000287Molecular functionmagnesium ion binding
GO_0004301Molecular functionepoxide hydrolase activity
GO_0033885Molecular function10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO_0015643Molecular functiontoxic substance binding
GO_0052642Molecular functionlysophosphatidic acid phosphatase activity
GO_0042577Molecular functionlipid phosphatase activity
GO_0016791Molecular functionphosphatase activity

IV. Literature review

[source]
Gene nameEPHX2
Protein nameBifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)]
Epoxide hydrolase 2
Synonyms
DescriptionFUNCTION: Bifunctional enzyme . The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides . Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators . .; FUNCTION: Bifunctional enzyme . The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid . Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates . .

AccessionsH0YAW7
ENST00000521780.5 [P34913-3]
ENST00000518328.5
ENST00000380476.7 [P34913-2]
P34913
ENST00000521684.1
ENST00000517536.5
E5RFU2
E5RFH6
ENST00000518379.5
E5RI53
ENST00000521400.6 [P34913-1]