EPHB4 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	15 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	13 studies	22% ± 5%	Explore
vein endothelial cell	9 studies	24% ± 12%	Explore
capillary endothelial cell	4 studies	22% ± 5%	Explore
epithelial cell	4 studies	19% ± 4%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPHB4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	7105.90	459 / 459	99%	73.38	1108 / 1118
lung	100%	6090.47	578 / 578	99%	67.98	1144 / 1155
esophagus	100%	3867.08	1444 / 1445	99%	82.91	181 / 183
intestine	100%	3847.51	966 / 966	98%	80.04	518 / 527
uterus	100%	11431.04	170 / 170	98%	65.33	451 / 459
prostate	100%	6337.60	245 / 245	98%	50.96	493 / 502
stomach	99%	3310.40	357 / 359	99%	69.59	282 / 286
pancreas	100%	2907.20	328 / 328	97%	67.01	173 / 178
bladder	100%	3591.62	21 / 21	96%	58.24	482 / 504
liver	100%	3465.07	226 / 226	96%	44.04	388 / 406
skin	100%	5514.47	1809 / 1809	90%	44.19	426 / 472
ovary	100%	7131.66	180 / 180	89%	37.93	382 / 430
thymus	100%	3960.71	652 / 653	86%	20.53	519 / 605
kidney	100%	4163.38	89 / 89	84%	29.99	759 / 901
adrenal gland	100%	9437.35	258 / 258	63%	34.46	144 / 230
adipose	100%	5311.92	1204 / 1204	0%	0	0 / 0
spleen	100%	9430.18	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.42	45 / 45
ureter	0%	0	0 / 0	100%	15.21	1 / 1
heart	97%	2507.99	838 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	79%	15.09	63 / 80
blood vessel	63%	1377.36	841 / 1335	0%	0	0 / 0
brain	10%	106.13	273 / 2642	42%	10.05	297 / 705
muscle	30%	338.13	243 / 803	0%	0	0 / 0
peripheral blood	30%	438.54	276 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	10%	1.26	3 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0002042	Biological process	cell migration involved in sprouting angiogenesis
GO_0033674	Biological process	positive regulation of kinase activity
GO_0001525	Biological process	angiogenesis
GO_0007275	Biological process	multicellular organism development
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0046777	Biological process	protein autophosphorylation
GO_0007155	Biological process	cell adhesion
GO_0003007	Biological process	heart morphogenesis
GO_0005829	Cellular component	cytosol
GO_0043235	Cellular component	receptor complex
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0005003	Molecular function	ephrin receptor activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity

Gene name	EPHB4
Protein name	receptor protein-tyrosine kinase (EC 2.7.10.1) Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Synonyms	HTK MYK1 hCG_20448 TYRO11 tcag7.1248
Description	FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. .
Accessions	ENST00000360620.7 ENST00000358173.8 [P54760-1] Q541P7 P54760 ENST00000616502.4 [P54760-3] Q96L35

EPHB4 report