EPHA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EPHA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EPHA1 at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0048013Biological processephrin receptor signaling pathway
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0045766Biological processpositive regulation of angiogenesis
GO_0090630Biological processactivation of GTPase activity
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0007275Biological processmulticellular organism development
GO_0033674Biological processpositive regulation of kinase activity
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0030335Biological processpositive regulation of cell migration
GO_0043087Biological processregulation of GTPase activity
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030336Biological processnegative regulation of cell migration
GO_0046777Biological processprotein autophosphorylation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0019901Molecular functionprotein kinase binding
GO_0001968Molecular functionfibronectin binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005005Molecular functiontransmembrane-ephrin receptor activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameEPHA1
Protein nameEphrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Alternative protein EPHA1
SynonymsEPHT1
EPHT
EPH
DescriptionFUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. .

AccessionsENST00000645847.2 [P21709-1]
P21709
ENST00000275815.4 [P21709-1]
L8EAE3