ENTPD5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009134Biological processnucleoside diphosphate catabolic process
GO_0006487Biological processprotein N-linked glycosylation
GO_0051084Biological process'de novo' post-translational protein folding
GO_0006011Biological processUDP-glucose metabolic process
GO_0006256Biological processUDP catabolic process
GO_0005615Cellular componentextracellular space
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0004382Molecular functionGDP phosphatase activity
GO_0045134Molecular functionUDP phosphatase activity
GO_0043262Molecular functionADP phosphatase activity
GO_1990003Molecular functionIDP phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0036384Molecular functionCDP phosphatase activity
GO_0017111Molecular functionribonucleoside triphosphate phosphatase activity

IV. Literature review

[source]
Gene nameENTPD5
Protein namenucleoside diphosphate phosphatase (EC 3.6.1.6) (Guanosine-diphosphatase ENTPD5) (Uridine-diphosphatase ENTPD5)
Nucleoside diphosphate phosphatase ENTPD5 (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Ectonucleoside triphosphate diphosphohydrolase 5) (NTPDase 5) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Inosine diphosphate phosphatase ENTPD5) (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5)
SynonymsPCPH
hCG_21714
CD39L4
DescriptionFUNCTION: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP . In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). .

AccessionsENST00000555829.5
O75356
ENST00000557325.5
G3V3Y0
H0YJH1
G3V450
ENST00000553284.5
ENST00000334696.11
ENST00000556242.5
G3V4I0