ENPP7 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENPP7 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	602.28	226 / 226	83%	16.42	337 / 406
kidney	97%	313.96	86 / 89	44%	2.91	399 / 901
spleen	92%	20.54	222 / 241	0%	0	0 / 0
lung	68%	4.89	391 / 578	1%	0.05	14 / 1155
pancreas	65%	2.94	213 / 328	3%	0.10	5 / 178
peripheral blood	55%	9.26	509 / 929	0%	0	0 / 0
intestine	48%	60.26	464 / 966	2%	0.09	10 / 527
adrenal gland	43%	1.60	111 / 258	1%	0.03	2 / 230
breast	41%	2.17	187 / 459	0%	0.02	4 / 1118
stomach	33%	1.33	118 / 359	5%	0.16	14 / 286
adipose	36%	1.45	429 / 1204	0%	0	0 / 0
thymus	32%	1.38	207 / 653	0%	0	0 / 605
bladder	29%	1.05	6 / 21	1%	0.03	6 / 504
brain	29%	1.16	770 / 2642	0%	0	0 / 705
prostate	27%	0.88	67 / 245	0%	0	0 / 502
esophagus	17%	0.66	241 / 1445	8%	0.32	14 / 183
blood vessel	23%	0.87	305 / 1335	0%	0	0 / 0
uterus	19%	0.63	33 / 170	1%	0.10	5 / 459
heart	20%	0.75	170 / 861	0%	0	0 / 0
ovary	19%	0.54	35 / 180	0%	0	0 / 430
muscle	15%	0.50	118 / 803	0%	0	0 / 0
skin	11%	0.56	207 / 1809	0%	0	0 / 472
lymph node	0%	0	0 / 0	10%	0.13	3 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_2000304	Biological process	positive regulation of ceramide biosynthetic process
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0045797	Biological process	positive regulation of intestinal cholesterol absorption
GO_2000755	Biological process	positive regulation of sphingomyelin catabolic process
GO_0008156	Biological process	negative regulation of DNA replication
GO_0055089	Biological process	fatty acid homeostasis
GO_1904729	Biological process	regulation of intestinal lipid absorption
GO_0044241	Biological process	lipid digestion
GO_0006684	Biological process	sphingomyelin metabolic process
GO_0046479	Biological process	glycosphingolipid catabolic process
GO_0005902	Cellular component	microvillus
GO_0005794	Cellular component	Golgi apparatus
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0004767	Molecular function	sphingomyelin phosphodiesterase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0008081	Molecular function	phosphoric diester hydrolase activity

Gene name	ENPP7
Protein name	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) (NPP-7) (EC 3.1.4.12) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase) Ectonucleotide pyrophosphatase/phosphodiesterase 7
Synonyms	UNQ3077/PRO9912
Description	FUNCTION: Choline-specific phosphodiesterase that hydrolyzes sphingomyelin releasing the ceramide and phosphocholine and therefore is involved in sphingomyelin digestion, ceramide formation, and fatty acid (FA) absorption in the gastrointestinal tract . Has also phospholipase C activity and can also cleave phosphocholine from palmitoyl lyso-phosphatidylcholine and platelet-activating factor (PAF) leading to its inactivation . Does not have nucleotide pyrophosphatase activity . May promote cholesterol absorption by affecting the levels of sphingomyelin derived from either diet or endogenous sources, in the intestinal lumen (By similarity). .
Accessions	I3L3G5 ENST00000328313.10 ENST00000576512.1 Q6UWV6

ENPP7 report