ENPP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048870Biological processcell motility
GO_2000394Biological processpositive regulation of lamellipodium morphogenesis
GO_0006935Biological processchemotaxis
GO_0006955Biological processimmune response
GO_0016192Biological processvesicle-mediated transport
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0030149Biological processsphingolipid catabolic process
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0030334Biological processregulation of cell migration
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0009395Biological processphospholipid catabolic process
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0003676Molecular functionnucleic acid binding
GO_0030247Molecular functionpolysaccharide binding
GO_0016787Molecular functionhydrolase activity
GO_0047391Molecular functionalkylglycerophosphoethanolamine phosphodiesterase activity
GO_0005044Molecular functionscavenger receptor activity
GO_0004622Molecular functionlysophospholipase activity
GO_0004528Molecular functionphosphodiesterase I activity
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameENPP2
Protein nameAlternative protein ENPP2
Ectonucleotide pyrophosphatase/phosphodiesterase 2
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) (EC 3.1.4.39) (Autotaxin) (Extracellular lysophospholipase D) (LysoPLD)
SynonymsATX
PDNP2
DescriptionFUNCTION: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids . Major substrate is lysophosphatidylcholine . Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility . Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP . Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation . Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein . May have a role in induction of parturition . Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor . Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids . Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) . .

AccessionsENST00000522826.5 [Q13822-3]
E5RIB9
Q13822
ENST00000520066.5
E7EUF1
ENST00000518958.1
ENST00000427067.6
E5RIA2
ENST00000259486.10 [Q13822-2]
ENST00000522167.5
L8ECC9
ENST00000075322.11 [Q13822-1]
E5RJ49