ENPP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENPP1 at tissue level.

III. Associated gene sets

GO_0055062Biological processphosphate ion homeostasis
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0090304Biological processnucleic acid metabolic process
GO_0032869Biological processcellular response to insulin stimulus
GO_0030643Biological processintracellular phosphate ion homeostasis
GO_0033198Biological processresponse to ATP
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0006796Biological processphosphate-containing compound metabolic process
GO_0030500Biological processregulation of bone mineralization
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0046034Biological processATP metabolic process
GO_0006955Biological processimmune response
GO_0030730Biological processsequestering of triglyceride
GO_0016192Biological processvesicle-mediated transport
GO_1990787Biological processnegative regulation of hh target transcription factor activity
GO_0030318Biological processmelanocyte differentiation
GO_0030505Biological processinorganic diphosphate transport
GO_0030502Biological processnegative regulation of bone mineralization
GO_0030282Biological processbone mineralization
GO_0009143Biological processnucleoside triphosphate catabolic process
GO_0050427Biological process3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO_0010467Biological processgene expression
GO_0031953Biological processnegative regulation of protein autophosphorylation
GO_0045719Biological processnegative regulation of glycogen biosynthetic process
GO_0046325Biological processnegative regulation of glucose import
GO_0030308Biological processnegative regulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0009986Cellular componentcell surface
GO_0005765Cellular componentlysosomal membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0005158Molecular functioninsulin receptor binding
GO_0004527Molecular functionexonuclease activity
GO_0003676Molecular functionnucleic acid binding
GO_0030247Molecular functionpolysaccharide binding
GO_0036221Molecular functionUTP diphosphatase activity
GO_0036219Molecular functionGTP diphosphatase activity
GO_0106177Molecular functioncyclic-GMP-AMP hydrolase activity
GO_0047693Molecular functionATP diphosphatase activity
GO_0005044Molecular functionscavenger receptor activity
GO_0050656Molecular function3'-phosphoadenosine 5'-phosphosulfate binding
GO_0004528Molecular functionphosphodiesterase I activity
GO_0047429Molecular functionnucleoside triphosphate diphosphatase activity
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0004551Molecular functiondinucleotide phosphatase activity
GO_0016791Molecular functionphosphatase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameENPP1
Protein nameEctonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
Ectonucleotide pyrophosphatase/phosphodiesterase 1
SynonymsM6S1
PC1
PDNP1
NPPS
DescriptionFUNCTION: Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals . Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP . May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling . Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function . Also involved in melanogenesis . Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production . 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear . Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP . .

AccessionsA0A3B3IST7
ENST00000647893.1
ENST00000650147.1
A0A3B3ISN7
ENST00000650507.1
ENST00000650437.1
A0A3B3IU14
ENST00000513998.5
E9PE72
P22413