ENDOV report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENDOV at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0005730Cellular componentnucleolus
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005737Cellular componentcytoplasm
GO_0003677Molecular functionDNA binding
GO_0016891Molecular functionRNA endonuclease activity, producing 5'-phosphomonoesters
GO_0016888Molecular functionendodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO_0005515Molecular functionprotein binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameENDOV
Protein nameEndonuclease V
Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease)
Synonyms
DescriptionFUNCTION: [Isoform 1]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine . Active against both single-stranded and double-stranded RNAs . Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) . Cleaves mRNAs and tRNAs containing inosine . Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' . Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures . .; FUNCTION: [Isoform 6]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine . Active against both single-stranded and double-stranded RNAs . Cleaves tRNAs containing inosine . .; FUNCTION: [Isoform 7]: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine . Active against both single-stranded and double-stranded RNAs . Cleaves tRNAs containing inosine . .

AccessionsENST00000522751.5
ENST00000517295.6
ENST00000520367.5 [Q8N8Q3-2]
ENST00000523999.5
ENST00000519117.5
ENST00000518644.5
ENST00000520484.1
ENST00000523828.5
ENST00000520284.5 [Q8N8Q3-4]
ENST00000523228.5
ENST00000572886.1
I3L0L4
ENST00000517795.5 [Q8N8Q3-5]
ENST00000518901.5 [Q8N8Q3-5]
E5RJ92
E5RHX4
H0YBZ5
A0A0G2JLD4
Q8N8Q3
E5RGZ9
I3L4M6
I3L1V3
ENST00000323854.9 [Q8N8Q3-3]
I3L485
H0YAY5
ENST00000522200.5
E5RII5
ENST00000521634.5
ENST00000519331.1
ENST00000522577.5
ENST00000518907.5 [Q8N8Q3-4]
I3L4V7
H0YBX8
ENST00000518137.6 [Q8N8Q3-1]
E5RFW0
ENST00000521565.5