ENDOG report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ENDOG at tissue level.

III. Associated gene sets

GO_0001701Biological processin utero embryonic development
GO_0090297Biological processpositive regulation of mitochondrial DNA replication
GO_0032007Biological processnegative regulation of TOR signaling
GO_0006974Biological processDNA damage response
GO_0034612Biological processresponse to tumor necrosis factor
GO_0010508Biological processpositive regulation of autophagy
GO_0046677Biological processresponse to antibiotic
GO_0006310Biological processDNA recombination
GO_0006309Biological processapoptotic DNA fragmentation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032043Biological processmitochondrial DNA catabolic process
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0004521Molecular functionRNA endonuclease activity
GO_0003676Molecular functionnucleic acid binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004520Molecular functionDNA endonuclease activity
GO_0000014Molecular functionsingle-stranded DNA endodeoxyribonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameENDOG
Protein nameEndonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)
Synonyms
DescriptionFUNCTION: Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA . The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four-stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified . Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response . GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation . Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication . .

AccessionsENST00000372642.5
Q14249