EMG1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EMG1 at tissue level.

III. Associated gene sets

GO_0070475Biological processrRNA base methylation
GO_0001824Biological processblastocyst development
GO_0017126Biological processnucleologenesis
GO_0006364Biological processrRNA processing
GO_0042274Biological processribosomal small subunit biogenesis
GO_0005730Cellular componentnucleolus
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0032040Cellular componentsmall-subunit processome
GO_0005737Cellular componentcytoplasm
GO_0019843Molecular functionrRNA binding
GO_0070037Molecular functionrRNA (pseudouridine) methyltransferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEMG1
Protein nameEMG1 nucleolar protein homolog (S. cerevisiae), isoform CRA_a (cDNA FLJ56921, highly similar to Probable ribosome biogenesis protein NEP1)
Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1)
EMG1 N1-specific pseudouridine methyltransferase
EMG1 N1-specific pseudouridine methyl transferase
SynonymsC2F
hCG_25956
DescriptionFUNCTION: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position . Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsQ92979
ENST00000599672.6
B4DP65
ENST00000539196.2
A0A0U3B3H7
A0A087WVM7