EME2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EME2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EME2 at tissue level.

III. Associated gene sets

GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0031297Biological processreplication fork processing
GO_0006302Biological processdouble-strand break repair
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0043596Cellular componentnuclear replication fork
GO_0048476Cellular componentHolliday junction resolvase complex
GO_1905347Cellular componentendodeoxyribonuclease complex
GO_0003677Molecular functionDNA binding
GO_0008821Molecular functioncrossover junction DNA endonuclease activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEME2
Protein nameEssential meiotic structure-specific endonuclease subunit 2
Probable crossover junction endonuclease EME2 (EC 3.1.22.-)
Synonyms
DescriptionFUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. .

AccessionsENST00000561903.6
ENST00000564182.1
A4GXA9
H3BSZ6
H3BV62
ENST00000568449.7 [A4GXA9-1]