EME1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EME1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EME1 at tissue level.

III. Associated gene sets

GO_0031573Biological processmitotic intra-S DNA damage checkpoint signaling
GO_0031297Biological processreplication fork processing
GO_0006302Biological processdouble-strand break repair
GO_0072429Biological processresponse to intra-S DNA damage checkpoint signaling
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0043596Cellular componentnuclear replication fork
GO_0000792Cellular componentheterochromatin
GO_0005730Cellular componentnucleolus
GO_0048476Cellular componentHolliday junction resolvase complex
GO_1905347Cellular componentendodeoxyribonuclease complex
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_0008821Molecular functioncrossover junction DNA endonuclease activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameEME1
Protein nameEssential meiotic structure-specific endonuclease 1
Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4)
SynonymsMMS4
DescriptionFUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. .

AccessionsENST00000511519.6
ENST00000393271.6 [Q96AY2-2]
ENST00000338165.9 [Q96AY2-1]
F8W714
H0Y9Z4
Q96AY2
ENST00000510246.1
ENST00000511711.5
D6RIT8
ENST00000511648.6 [Q96AY2-2]