EMC8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EMC8 at tissue level.

III. Associated gene sets

GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0045050Biological processprotein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO_0005737Cellular componentcytoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0072546Cellular componentEMC complex
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEMC8
Protein nameER membrane protein complex subunit 8
ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B)
SynonymsCOX4NB
FAM158B
C16orf4
COX4AL
C16orf2
NOC4
DescriptionFUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins . Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues . Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices . It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes . By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors . By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). .

AccessionsM0R1B0
O43402
ENST00000253457.8 [O43402-1]
ENST00000435200.2 [O43402-2]
ENST00000595980.5