Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 22% ± 9% | |
| oligodendrocyte | 6 studies | 24% ± 7% | |
| microglial cell | 5 studies | 24% ± 6% | |
| astrocyte | 5 studies | 29% ± 10% | |
| oligodendrocyte precursor cell | 5 studies | 29% ± 11% | |
| GABAergic neuron | 4 studies | 41% ± 14% | |
| glutamatergic neuron | 4 studies | 44% ± 17% | |
| macrophage | 4 studies | 23% ± 5% | |
| epithelial cell | 3 studies | 43% ± 24% | |
| lymphocyte | 3 studies | 19% ± 0% | |
| fibroblast | 3 studies | 19% ± 4% | |
| endothelial cell of lymphatic vessel | 3 studies | 18% ± 1% | |
| interneuron | 3 studies | 41% ± 20% | |
| neuron | 3 studies | 38% ± 18% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 38% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1714.69 | 245 / 245 | 100% | 20.72 | 502 / 502 |
| brain | 100% | 1996.94 | 2641 / 2642 | 100% | 36.38 | 705 / 705 |
| breast | 100% | 1712.81 | 459 / 459 | 100% | 26.62 | 1116 / 1118 |
| thymus | 100% | 1695.17 | 653 / 653 | 100% | 25.67 | 603 / 605 |
| lung | 100% | 1412.94 | 576 / 578 | 100% | 19.30 | 1154 / 1155 |
| uterus | 100% | 1947.45 | 170 / 170 | 100% | 26.20 | 457 / 459 |
| ovary | 100% | 1821.97 | 180 / 180 | 100% | 17.90 | 428 / 430 |
| esophagus | 100% | 1625.92 | 1445 / 1445 | 99% | 14.54 | 182 / 183 |
| intestine | 100% | 1777.39 | 966 / 966 | 99% | 19.34 | 524 / 527 |
| kidney | 100% | 1609.45 | 89 / 89 | 99% | 25.30 | 895 / 901 |
| stomach | 100% | 1237.53 | 359 / 359 | 99% | 18.62 | 284 / 286 |
| skin | 100% | 1789.12 | 1809 / 1809 | 99% | 30.91 | 468 / 472 |
| bladder | 100% | 1955.81 | 21 / 21 | 98% | 18.90 | 496 / 504 |
| pancreas | 99% | 830.29 | 324 / 328 | 99% | 18.80 | 177 / 178 |
| liver | 100% | 1375.18 | 226 / 226 | 98% | 15.37 | 398 / 406 |
| adrenal gland | 100% | 1783.06 | 258 / 258 | 97% | 19.74 | 224 / 230 |
| adipose | 100% | 1693.16 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1572.73 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 25.41 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 26.84 | 29 / 29 |
| muscle | 100% | 2359.73 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1836.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 21.83 | 45 / 45 |
| heart | 99% | 1304.76 | 850 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 1211.42 | 845 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0001764 | Biological process | neuron migration |
| GO_0006417 | Biological process | regulation of translation |
| GO_0002098 | Biological process | tRNA wobble uridine modification |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0002926 | Biological process | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| GO_0007417 | Biological process | central nervous system development |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0033588 | Cellular component | elongator holoenzyme complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0106261 | Molecular function | tRNA uridine(34) acetyltransferase activity |
| GO_0008607 | Molecular function | phosphorylase kinase regulator activity |
| GO_0016407 | Molecular function | acetyltransferase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0000049 | Molecular function | tRNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| Gene name | ELP3 |
| Protein name | Elongator acetyltransferase complex subunit 3 Elongator complex protein 3 (EC 2.3.1.-) Elongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase) |
| Synonyms | |
| Description | FUNCTION: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) . In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase . Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation . Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). . FUNCTION: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. . |
| Accessions | ENST00000520270.5 ENST00000518112.5 E5RHY2 E5RIC0 ENST00000537665.2 [Q9H9T3-4] ENST00000523357.5 ENST00000380353.8 [Q9H9T3-5] ENST00000521015.5 [Q9H9T3-2] E5RHR2 ENST00000524103.5 ENST00000520288.5 H0YAP7 ENST00000521570.5 ENST00000256398.13 [Q9H9T3-1] ENST00000519261.5 ENST00000523687.5 E5RG26 ENST00000521099.1 ENST00000517975.1 H0YC54 Q9H9T3 E5RIU1 B4DKA4 E5RIZ7 |