ELP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0001764Biological processneuron migration
GO_0006417Biological processregulation of translation
GO_0002098Biological processtRNA wobble uridine modification
GO_0030335Biological processpositive regulation of cell migration
GO_0002926Biological processtRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO_0007417Biological processcentral nervous system development
GO_0005730Cellular componentnucleolus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0033588Cellular componentelongator holoenzyme complex
GO_0005634Cellular componentnucleus
GO_0106261Molecular functiontRNA uridine(34) acetyltransferase activity
GO_0008607Molecular functionphosphorylase kinase regulator activity
GO_0016407Molecular functionacetyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0000049Molecular functiontRNA binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding

IV. Literature review

[source]
Gene nameELP3
Protein nameElongator acetyltransferase complex subunit 3
Elongator complex protein 3 (EC 2.3.1.-)
Elongator complex protein 3 (hELP3) (EC 2.3.1.-) (tRNA uridine(34) acetyltransferase)
Synonyms
DescriptionFUNCTION: Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) . In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase . Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation . Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). .

FUNCTION: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. .

AccessionsENST00000520270.5
ENST00000518112.5
E5RHY2
E5RIC0
ENST00000537665.2 [Q9H9T3-4]
ENST00000523357.5
ENST00000380353.8 [Q9H9T3-5]
ENST00000521015.5 [Q9H9T3-2]
E5RHR2
ENST00000524103.5
ENST00000520288.5
H0YAP7
ENST00000521570.5
ENST00000256398.13 [Q9H9T3-1]
ENST00000519261.5
ENST00000523687.5
E5RG26
ENST00000521099.1
ENST00000517975.1
H0YC54
Q9H9T3
E5RIU1
B4DKA4
E5RIZ7