ELL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0042796Biological processsnRNA transcription by RNA polymerase III
GO_0042795Biological processsnRNA transcription by RNA polymerase II
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0032786Biological processpositive regulation of DNA-templated transcription, elongation
GO_0001701Biological processin utero embryonic development
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0015030Cellular componentCajal body
GO_0016607Cellular componentnuclear speck
GO_0000791Cellular componenteuchromatin
GO_0035363Cellular componenthistone locus body
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0008023Cellular componenttranscription elongation factor complex
GO_0019902Molecular functionphosphatase binding
GO_0005515Molecular functionprotein binding
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding

IV. Literature review

[source]
Gene nameELL
Protein nameElongation factor for RNA polymerase II
RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)
ELL_HUMAN
SynonymsC19orf17
DescriptionFUNCTION: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III . Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription . ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. .

AccessionsU3KQA3
ENST00000262809.9
U3KQ90
ENST00000594635.6
P55199
Q75MS0
ENST00000596124.3