ELAVL4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905870Biological processpositive regulation of 3'-UTR-mediated mRNA stabilization
GO_0031099Biological processregeneration
GO_0006397Biological processmRNA processing
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0048813Biological processdendrite morphogenesis
GO_0006396Biological processRNA processing
GO_0140245Biological processregulation of translation at postsynapse
GO_0008306Biological processassociative learning
GO_0042220Biological processresponse to cocaine
GO_1900006Biological processpositive regulation of dendrite development
GO_0008380Biological processRNA splicing
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0007626Biological processlocomotory behavior
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0021895Biological processcerebral cortex neuron differentiation
GO_0098978Cellular componentglutamatergic synapse
GO_0005840Cellular componentribosome
GO_0043204Cellular componentperikaryon
GO_0098794Cellular componentpostsynapse
GO_0005635Cellular componentnuclear envelope
GO_0030425Cellular componentdendrite
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0097440Cellular componentapical dendrite
GO_0030424Cellular componentaxon
GO_1990904Cellular componentribonucleoprotein complex
GO_0008143Molecular functionpoly(A) binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0097158Molecular functionpre-mRNA intronic pyrimidine-rich binding

IV. Literature review

[source]
Gene nameELAVL4
Protein nameELAV like RNA binding protein 4
ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD)
ELAV-like protein
SynonymsPNEM
HUD
hCG_2031550
DescriptionFUNCTION: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs . Plays a role in the regulation of mRNA stability, alternative splicing and translation . Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA . Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay . Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding . Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms . Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression . Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization . Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain . By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing . Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing . May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA . .

AccessionsENST00000650764.1
ENST00000652353.1
ENST00000357083.8
ENST00000651258.1
ENST00000371819.1
A0A494C147
A0A494C0F8
ENST00000371821.6 [P26378-6]
A0A494C0M6
ENST00000371824.7 [P26378-2]
P26378
ENST00000652274.1
A0A494C0Q5
B1APY9
A0A494BZW4
A0A494C015
A0A494C173
A0A494C1D9
A0A0R4J2E6
ENST00000371823.8 [P26378-1]
ENST00000652693.1
ENST00000651347.1
ENST00000651693.1
ENST00000448907.7 [P26378-5]
ENST00000494555.2
ENST00000463650.2
ENST00000371827.5 [P26378-4]
A0A494C011