EIF4ENIF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0006412Biological processtranslation
GO_0051168Biological processnuclear export
GO_0033962Biological processP-body assembly
GO_0048255Biological processmRNA stabilization
GO_0030182Biological processneuron differentiation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0019827Biological processstem cell population maintenance
GO_0006606Biological processprotein import into nucleus
GO_0017148Biological processnegative regulation of translation
GO_0106289Biological processnegative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0019900Molecular functionkinase binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005049Molecular functionnuclear export signal receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF4ENIF1
Protein nameEukaryotic translation initiation factor 4E nuclear import factor 1
eIF4ENIF1 protein
Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)
Synonyms
DescriptionFUNCTION: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) . Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation . Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation . Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression . Required for the formation of P-bodies . Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay . Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism . .

AccessionsB1AKL5
ENST00000397523.5
ENST00000330125.10 [Q9NRA8-1]
ENST00000397525.5 [Q9NRA8-1]
ENST00000397520.1
ENST00000423097.5
H7C0J7
ENST00000445424.5
Q6PJR2
ENST00000344710.9 [Q9NRA8-2]
Q9NRA8
B1AKL6
ENST00000397518.5
B0QYZ7
B1AKL4
ENST00000418321.1